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However, considering the recently observed associations between the intestinal microbiome and a whole range of effects on the brain, immunology, and rheumatoid arthritis it is attractive to speculate that many of these associations with endometriosis might also find their origin in hereditary factors increasing the risk of endometriosis and changing the bowel microbiota as reviewed in 42 articles in 2021 only [51,52,53,54,55,56,57,58,59,60])

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Estrogens have been proposed to act as protective factors by certain authors, but as pathogenic determinants of osteoarthritis by others (36)